Uncover the secrets to a longer, healthier life as we delve into the world of geroscience, where top longevity scientists share their personal strategies for reducing biological age. From drugs and supplements to lifestyle changes, these experts reveal what they do to add years to their lives. But be warned, not all advice is created equal, and some strategies may be more controversial than others. So, let's explore the science behind these claims and see what works and what doesn't. But here's where it gets controversial...
The quest for longevity has led to the development of geroscience, a revolutionary field that aims to slow down the ageing process. Scientists are testing drugs designed to prevent age-related diseases, helping people live healthier for longer. Ageing is a major driver of illness, as damaged cells accumulate and leak inflammatory chemicals, while the body becomes less able to repair itself. This increases the chances of diseases like cancer, dementia, and heart problems.
One potential breakthrough comes from Mabwell, a biotech company that has started human tests of a drug blocking interleukin-11 (IL-11), a molecule that increases with age and leads to chronic inflammation. Research has shown that raised IL-11 levels are linked to more aggressive cancers and lowered survival rates.
Another promising drug is GLP-1, such as semaglutide (brand names Ozempic and Wegovy), which was developed for diabetes and weight loss but may also slow age-related diseases. A study found that semaglutide reduced heart attacks and strokes by 20% in people with obesity and cardiovascular disease, and may have other protective effects.
But what about the geroscientists themselves? What are they doing to add healthy years to their lives? As they told Good Health, the evidence-based steps they're taking aren't just about the obvious things like exercise and diet. For instance, Matt Kaeberlein, a professor of the biology of ageing, takes a cholesterol-lowering drug and a drug for type 2 diabetes and heart failure.
However, not all advice is created equal, and some strategies may be more controversial than others. For example, some experts avoid anti-ageing supplements targeting NAD, while others take rapamycin, a drug designed to stop organ transplant rejection that's been found to slow ageing. But be warned, not all advice is created equal, and some strategies may be more controversial than others.
So, what's the verdict? While there are no miracle fixes, these scientists agree that ageing can be slowed through lifestyle modification and proactive healthcare. But remember, consult with a medical professional before making any significant changes to your diet or taking new supplements.
